General Introduction
Dr. Sam Kassegne holds a Ph.D. degree in engineering mechanics
from Virginia Polytechnic Institute and State University. His
research interests are in the areas of MEMS and integrated micro-
and nano-fabrication technologies. His experimental research work
is focused primarily in developing novel applications of microfluidics/nanofluidics
and microarray technology in areas such as DNA/Protein chips,
hand-held point-of-care diagnostic systems, as well as polymer
photovoltaic technology. His lab has a strong focus on developing
the next generation of integrated micro- and nano-lithography
technology for a variety of application areas. Other focus areas
include MEMS-based IMUs. Dr. Kassegne has an extensive industrial
experience in MEMS, biotech and computational sciences acquired
through his employment at Nanogen, Microfabrica and Bentley Systems
in Southern California as well as consultancy work for Corning,
SAIC, Nevada Nanotech, and Nokia. He has also taught courses at
UCSD and UCI.


Our new Class
100 cleanroom facility
Research Sponsors



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Research Groups
We are a research group in the mechanical engineering
department at San Diego State University in southern California.
Our team includes mechanical, bio/biomedical, chemical, electrical
as well as materials engineers. General research areas include
micro and nanofabrication, microfluidics/nanofluidics, Microarrays
and DNA/Protein chips, Micro Electro-Mechanical Systems (MEMS) emerging
technologies in IMUs (applications in cell phone, navigation systems,
and image stabilization), polymer-based photovoltaic technology,
and computational sciences (modeling multi-physics and reaction
engineering in life sciences and electrochemical systems). Our group
collaborates with researchers at our institution and other national
MEMS programs (including the various academic and industrial groups
that spun-off the core Nanogen technology). We also have an active
international program involving seminars and joint research. Our
new class 100 cleanroom facility (400 sq. ft.) is equipped for most
lithography processes as well as some characterizations.
  
Current Group Members: Bao
Nguyen, Berhanu Wondimu, Saravana Pitchaikani, Phoebe Shin, Neeraj
Yadav, Bhuvnesh Arya, Nithesh Paramesh, Nitin Hardwood, Mike Frank,
Amandeep Singh, and Sai Chand Inala. (Alumin: Lei Zhou, Zaid Karim,
Vaibhav Patel, Steven Wong, Alex Teeter, and Sahil Patel).
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(I) Microfluidics Group
Research in this area encompasses FEA/CFD
simulation of flows, electrokinetic and other body forces,
and localized phenomena (such as Joule heating, surface tension,
etc) within micron and nano-scale channels. Simulations
are utilized for experimental validations. Applications
for such development include miniaturized biological assay
transport, selective charged-particle separation, and systems
of reduced volumes for pathogen detection.
Current active research also include new magneto-hydrodynamic
(MHD) micropump designs with bubble-isolating micro-channels
and high-efficiency stacked 3D centrigugal micropumps. Both
experimental and theoretical/simulation research is pursued.
Researchers: Bao Nguyen, Saravana Pitchaikani,
Nitin, Nithesh, and Vaibhav Patel (currently at Qualcomm MEMS
Technologies).

BIRS (Bubble Isolation & Release System)
MHD micropump. B. Nguyen.

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(II) BioChip Group
DNA/Protein chips (microarrays)
Coupled with our research in microfluidics,
these projects include strides towards Sample-to-Answer
technologies. Utilizing the innate charge of DNA and
the electrical polarizability of other biomolecules, our group
is making strides towards improved separation techniques requiring
minimal reagent volume.
3D Manipulation/Separation
We have developed several designs for selective
manipulation of colloids and individual particles in 3D.
Dimensional extension of such manipulations has many applications
ranging from molecular diagnostic and pathogen detection systems
to nano-assembly. We are currently working on some specific
aspects of 3D carbon microelectrode array for biochips (courtesy
of collaboration with Marc Madou's group @ UCI).

Researchers: Phoebe
Shin, Namratha Tata, Vinot Vijayaraghavan.
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(III) IMU Group (Accelero & Gyro)
We are working on novel tunable 2-axis and 3-axis MEMS accelerometers
& gyroscopes. An ongoing research project has a wide application
in cell phones, gaming, energy harvesting, and image stabilization.
 
Researchers: Amandeep Singh and Berhanu Wondimu.
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(IV) Nanofabrication Group
We are working on innovative hierarchical micro and
nanofabrication technologies. One approach we are pursuing
is IMN-litho (Integrated Micro/nano) lithography that shows
promise in machining biochips with both micro and nano features.
Collaborators: Dr. Moon and Morsi @ SDSU.
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News/People
Recent Graduates (06-Present)
- Alex Teeter - MS Thesis - Defended in March 06. Currently at
Gen-Probe - San Diego.
- Sahil Patel - MEng - Defended in July 06.
- Vaibhav Patel - MS Thesis - Defended in March 07. Currently
at Qualcomm MEMS Technologies, San Jose, CA.
- Lei Zhou - MS Thesis (EE) - Defended in December 06.
- Zaid Karim - MS Thesis (double thesis) - Defended in December
06. Currently at NAVAIR - San Diego.
- Steven Wong - MS Thesis (Bioengineering) - Defended in May 2007.
Currently at Guidant (Abbott Labs) near San Diego.
- Bao Nguyen - MS Thesis (Bioengineering) - Defended in Dec 2007.
Currently at Arrayomics in San Diego.
- Saravana Pitchaikani - MEng - Defended in Dec 2007.
- Phoebe Shin - MS Thesis - Defended in Jan 2008. Currently at
AutoSplice.
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